Organic phosphoric acids and derivatives
Sigma Aldrich Fine Chemicals Biosciences 4-METHYLUMBELLIFERYL PHOSPHATE
NC3875891 4-METHYLUMBELLIFERYL PHOSPHATE
Medchemexpress LLC DOPE | 4004-05-1 | 99.96% | 744.03 | 50 MG
DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid that combines with cationic phospholipids to improve the transfection efficiency of naked siRNA, and it is also an endogenous metabolite. In studies, DOPE-containing liposomes (LNP) exhibited a knock-down (KD) effect on macrophages and dendritic cells and showed fusogenicity. LNP/siRNA significantly suppressed CD45 protein expression, demonstrating potential as an efficient siRNA delivery system for both murine and human macrophages and dendritic cells.
- Neutral helper lipid for cationic liposomes
- Improves transfection efficiency of naked siRNA
- Exerts knock-down (KD) effect on macrophages and dendritic cells
- Liposomes containing DOPE show fusogenicity
- Potential for efficient siRNA delivery system
- Endogenous metabolite
Sigma Aldrich Fine Chemicals Biosciences SIGMAFAST(TM) p-Nitrophenyl phosphate Tablets tablet, To prepare 20 mL | MFCD00284586 | 50SET
SIGMAFAST(TM) p-Nitrophenyl phosphate Tablets tablet, To prepare 20 mL | MFCD00284586 | 50SET
Medchemexpress LLC 1,2-dimyristoyl-d54-sn-glycero-3-phosphocholine | 78415-49-3 | >99.0% | 732.27 g·mol⁻¹ | C36H18D54NO8P | 5 MG
1,2-dimyristoyl-d54-sn-glycero-3-phosphocholine is a perdeuterated phosphatidylcholine used as an isotopically labeled model lipid for membrane biophysics and structural studies such as neutron scattering and deuterium NMR.
- Perdeuterated fatty acyl chains provide strong contrast for neutron scattering.
- High isotopic and chemical purity (>99%).
- Compatible with deuterium NMR and other spectroscopic techniques.
- Used to form model membranes, liposomes, and supported bilayers.
- Supplied as a dry powder suitable for dispersion and vesicle preparation.
Medchemexpress LLC Diethyl mesoxalate | 609-09-6 | MFCD00009121 | 99.5% | 174.15 g·mol⁻¹ | C7H10O5 | 250 G
1,3-Diethyl 2-oxopropanedioate (diethyl mesoxalate) is the diethyl ester of mesoxalic acid used as an organic intermediate and biochemical reagent in synthetic chemistry and life-science research. It is a small-molecule building block (CAS 609-09-6; formula C7H10O5; MW 174.15 g·mol⁻¹) typically supplied for research use with high assay purity.
- High purity suitable for analytical and synthetic applications.
- Useful as a building block in organic and medicinal chemistry syntheses.
- Intended for research use only; not for human or diagnostic applications.
- Available in multiple pack sizes to support lab-scale workflows.
- Commonly referenced in chemical databases and supplier datasheets for identity confirmation.
Medchemexpress LLC 1,2-Dioleoyl-sn-glycero-3-phosphate sodium salt (18:1 PA sodium salt) | 108392-02-5 | 99.4% | 722.95 | 25 MG
1,2-Dioleoyl-sn-glycero-3-phosphate sodium salt (18:1 PA sodium salt) | 108392-02-5 | 99.4% | 722.95 | 25 MG
Apexbio Technology LLC Pyridoxal 5 phosphate 54-47-7 100mg
Pyridoxal 5-phosphate (CAS 54-47-7) is a biologically active derivative of vitamin B6 functioning primarily as a coenzyme in numerous enzymatic reactions It is designed to facilitate amino acid metabolism and biosynthesis pathways including neurotransmitter and sphingolipid synthesis as well as porphyrin biosynthesis Pyridoxal 5-phosphate exerts its biological activity primarily through coenzyme-mediated facilitation of transamination and other enzymatic transformations Its activity and affinity vary depending on the specific enzyme involved with reported enzyme IC50 values ranging broadly depending on enzyme type and experimental conditions Based on these pharmacological properties Pyridoxal 5-phosphate holds research potential in elucidating enzyme mechanisms metabolic pathway profiling assay optimization and the study of biosynthetic processes
Apexbio Technology LLC KN-93 Phosphate 1188890-41-6 10mg
KN-93 Phosphate (CAS 1188890-41-6) is a small-molecule inhibitor targeting calcium/calmodulin-dependent protein kinase II (CaMKII) It is designed to selectively inhibit CaMKII thereby modulating cellular proliferation survival neurotransmitter regulation and related signal transduction pathways KN-93 Phosphate exerts its biological activity primarily by competitively binding to Ca2 /calmodulin disrupting their interaction with CaMKII and preventing CaMKII activation and autophosphorylation In cell-based studies KN-93 Phosphate demonstrates inhibitory activity with IC50 values of 9 M for CaMKII monomer and 3 M for CaMKII dodecamer Experimental models include hepatic stellate cells and NIH 3T3 fibroblasts Based on these pharmacological properties KN-93 Phosphate holds research potential in the study of cell cycle regulation apoptosis neurotransmitter synthesis and neurodegenerative disorders particularly Parkinson s disease models
Apexbio Technology LLC KN-93 Phosphate 1188890-41-6 10mM (in 1mL DMSO)
KN-93 Phosphate (CAS 1188890-41-6) is a small-molecule inhibitor targeting calcium/calmodulin-dependent protein kinase II (CaMKII) It is designed to selectively inhibit CaMKII thereby modulating cellular proliferation survival neurotransmitter regulation and related signal transduction pathways KN-93 Phosphate exerts its biological activity primarily by competitively binding to Ca2 /calmodulin disrupting their interaction with CaMKII and preventing CaMKII activation and autophosphorylation In cell-based studies KN-93 Phosphate demonstrates inhibitory activity with IC50 values of 9 M for CaMKII monomer and 3 M for CaMKII dodecamer Experimental models include hepatic stellate cells and NIH 3T3 fibroblasts Based on these pharmacological properties KN-93 Phosphate holds research potential in the study of cell cycle regulation apoptosis neurotransmitter synthesis and neurodegenerative disorders particularly Parkinson s disease models
eMolecules 6064-14-8 | 1,3-Bis(2-methoxy-5-(trifluoromethyl)phenyl)urea | Synthonix - Stock | MFCD30748125 | 408.300 | C17H14F6N2O3 | 95.000 | COc1ccc(cc1NC(=O)Nc1cc(ccc1OC)C(F)(F)F)C(F)(F)F | 5g | 495866238
1,3-Bis(2-methoxy-5-(trifluoromethyl)phenyl)urea | Synthonix - Stock | 6064-14-8 | MFCD30748125 | 408.300 | C17H14F6N2O3 | 95.000 | COc1ccc(cc1NC(=O)Nc1cc(ccc1OC)C(F)(F)F)C(F)(F)F | 5g | 495866238
Medchemexpress LLC 1,2-dioleoyl-sn-glycerol | 24529-88-2 | MFCD00148866 | 100.0% | C39H72O5 | 10MG
1,2-Dioleoyl-sn-glycerol is a diacylglycerol lipid used as a biochemical research reagent and assay substrate. It provides a physiologically relevant 18:1/18:1 diacylglycerol species for enzyme and signaling studies, and is supplied with documentation for quality and safety. Intended for in vitro research use; follow storage and solvent recommendations for stability and solubility.
- High purity suitable for biochemical assays.
- Provides physiologically relevant 18:1/18:1 diacylglycerol species.
- Supplied with COA and SDS for quality and safety documentation.
- Soluble in DMSO and ethanol with ultrasonic assistance.
- Stable when stored at -20°C; in solvent store at -80°C for extended periods.
- Liquid form simplifies preparation of assay solutions.
Medchemexpress LLC 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine (sodium) | 90693-88-2 | 98.0% | C42H77NNaO10P | 250 MG
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine (sodium) | 90693-88-2 | 98.0% | C42H77NNaO10P | 250 MG
Medchemexpress LLC Sphingosine-1-phosphate (S1P) | 26993-30-6 | 99.0% | 379.47 | 10 MG
Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6, and GPR12. It functions as an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors. S1P is a significant lipid mediator produced from Sphingomyelin or other membrane phospholipids.
- Stimulates DNA synthesis
- Promotes cell proliferation
- Facilitates cell migration